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Madikwe is a malaria free area situated in the North West Province of South Africa. Located in South Africa along the Botswana border and 20 km from Gaberone. Madikwe lies within a transition region between lowveld bushveld and the Kalahari thornveld. As a result the region is host to an incredible diversity of species from both ecosystems. Geographically the region has enormous volcanic intrusions known as Inselbergs, which are prominent throughout. Madikwe is home to a tremendous diversity of fauna and flora, including the black and white rhino, buffalo, elephant, lion, leopard, cheetah and wild dog.

Madikwe is regarded as one of the finest conservation areas in Africa, offering all the major species, including lion, leopard, elephant, buffalo, both white and black rhino along with almost all the plains antelope species. A special feature of Madikwe lies in its unique location, a transition zone on the edges of the Kalahari, where a number of rare species occur naturally. The climate is generally mild to hot, but winter nights can be cold.